Product Name	RIC8A
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	C8E2
React Species	Human
Applications	WB=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	鸟嘌呤核苷酸交换因子（GEF），它可以激活一些，但不是所有的G-α蛋白。能够激活GNAI1、GNAO1和GNAQ，但不能通过将约束GDP交换为GTP来激活GNAS。通过刺激G（i）-α蛋白参与染色体有丝分裂运动期间微管拉力的调节，可能导致从NuMA-GPSM2-G（i）-α-GDP复合体释放G（i）-αGTP和NuMA蛋白。通过增强G（q）偶联受体介导的ERK激活，还作为G（q）-α（GNAQ）蛋白的激活剂。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: HeLa, 293, Raji, A431 Protein loading quantity: 20 μg Exposure time: 3 s Predicted MW: 65 kDa Observed MW: 65 kDa

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