Product Name	DDOST
Chinese Name	晚期糖基化终产物受体1抗体
Alias	Advanced glycation endproduct receptor 1; AGE R1; AGER1; CDG1R; DDOST 48 kDa subunit; Dolichyl diphosphooligosaccharide protein glycosyltransferase subunit (non catalytic); Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Dolichyl-diphosphooligosaccharide-protein glycosyltransferase; EC 2.4.1.119; KIAA0115; MGC2191; OK/SW-cl.45; OKSWcl45; Oligosaccharyl transferase 48 kDa subunit; Oligosaccharyltransferase 48 kDa subunit; Oligosaccharyltransferase subunit 48; OST; OST48; OST48_HUMAN; RP23-25C1.4; WBP1; wu:fa11d01; zgc:66068; zgc:77478.
Research Area	immunology  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Zebrafish, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DDOST/AGER1: 361-456/456
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008] Function: DDOST (Dolichyl-diphosphooligosaccharide-protein glycosyltransferase) is a component of the oligosaccharyltransferase complex. This complex catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum and co-purifies with ribosomes. DDOST is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes even after release from the ribosome. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Database links. DISEASE: Congenital disorder of glycosylation 1R (CDG1R) [MIM:614507]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the DDOST 48 kDa subunit family. SWISS: P39656 Gene ID: 1650 Database links: Entrez Gene: 1650 Human Entrez Gene: 425542 Chicken Entrez Gene: 510682 Cow Entrez Gene: 404012 Dog Entrez Gene: 13200 Mouse Entrez Gene: 313648 Rat Entrez Gene: 444283 Xenopus laevis Entrez Gene: 100145597 Xenopus tropicalis Entrez Gene: 406408 Zebrafish Omim: 602202 Human SwissProt: P48440 Chicken SwissProt: A6QPY0 Cow SwissProt: Q05052 Dog SwissProt: P39656 Human SwissProt: O54734 Mouse SwissProt: Q641Y0 Rat SwissProt: Q6GNR9 Xenopus laevis SwissProt: B1H3C9 Xenopus tropicalis SwissProt: Q6NYS8 Zebrafish Unigene: 523145 Human

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