Product Name	PSMA1
Chinese Name
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	C12B5
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,ICC/IF=1:50-200,Flow-Cyt=1:50-100,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	参与大多数细胞内蛋白质水解降解的20S核心蛋白酶体复合体的成分。这种复合物通过与不同的调控粒子结合，在细胞内发挥许多重要作用。与两个19S调节颗粒结合，形成26S蛋白酶体，从而参与Ubiquitin化蛋白质的ATP依赖性降解。26S蛋白酶体通过去除可能损害细胞功能的错误折叠或受损蛋白质，以及去除不再需要功能的蛋白质，在维持蛋白质内稳态中发挥关键作用。与PA200或PA28相关，20S蛋白酶体介导Ubiquitin非依赖性蛋白质降解。这种类型的蛋白水解在包括精子发生（20S-PA200复合物）或产生MHC I类抗原肽（20S-PA28复合物）子集在内的几种途径中是必需的。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: HeLa, MCF-7, Mouse liver, Rat brain Protein loading quantity: 20 μg Exposure time: 3 s Predicted MW: 30 kDa Observed MW: 30 kDa

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