Product Name	RBBP4
Chinese Name	视网膜母细胞瘤Binding proteinP48Recombinant rabbit monoclonal anti
Alias	RBBP4_HUMAN; Histone-binding protein RBBP4; Chromatin assembly factor 1 subunit C; CAF-1 subunit C; Chromatin assembly factor I p48 subunit; CAF-I 48 kDa subunit; CAF-I p48; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4; RBBP-4; Retinoblastoma-binding protein p48; RbAp48.
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	G7A9
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,Flow-Cyt=1:50-100,ICC/IF=1:50-200（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] SWISS: Q09028 Gene ID: 5928 核心组蛋白结合亚单位，可靶向染色质组装因子、染色质重塑因子和组蛋白脱乙酰基酶，其方式由核小体DNA调节。是几种调节染色质代谢的复合物的成分。这些包括染色质组装因子1（CAF-1）复合物，它是DNA复制和DNA修复后染色质组装所必需的。核心组蛋白去乙酰化酶（HDAC）复合物，促进组蛋白去乙酰化和随后的转录抑制，核小体重构和组蛋白去乙酰化酶复合物（NuRD复合物），通过组蛋白去乙酰化和核小体重构促进转录抑制。PRC2/EED-EZH2复合物，在发育过程中促进同源异型基因的抑制。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: HeLa,HEK- 293, A20, Rat spleen Protein loading quantity: 20 μg Exposure time: 3 s Predicted MW: 52 kDa Observed MW: 52 kDa Tissue: Human lung squamous carcinoma Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:100 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Rabbit) (sp-0023) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60573R

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