Product Name	ABCE1
Chinese Name
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	A12F4
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,ICC/IF=1:50-200,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,Flow-Cyt=1:50-100,IP=1:20-50 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	共翻译质量控制因子参与了不通过衰变（NGD）途径。与PELO和HBS1L一起，是80S核糖体形成48S复合物和空位80S核糖体解离所必需的。与PELO和HBS1L一起识别停滞的核糖体并促进组装在不间断mRNAs上的延伸复合物的解离，这触发了mRNA的核内裂解，这是一种释放非功能性核糖体和降解受损mRNAs的机制，是No-Go衰变（NGD）途径的一部分。在mRNA周转的调控中起作用，在Mitochondrion外膜定位mRNA翻译的质量控制中起作用。作为PINK1调控信号的一部分，在Mitochondrion损伤时被CNOT4Ubiquitin化；这种修饰产生多Ubiquitin信号，将自噬受体招募到Mitochondrion外膜并启动有丝分裂吞噬。RNASEL特异性蛋白抑制剂，拮抗2-5A（5'-磷酸化2'，5'-连接的寡腺苷酸）与RNASEL的结合。Interferon调节的2-5A/RNASEL途径抗病毒作用的负调节因子。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: room temperature 2h Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1:HeLa, 2: Panc-1, 3: Mouse liver Protein loading quantity: 20 μg Exposure time: 10 s Predicted MW: 67 kDa Observed MW: 67 kDa Cell line: HeLa Fixative: 4% Paraformaldehyde Permeabilization: 0.1% TritonX-100 Primary ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60444R Cell line: NIH-3T3 Fixative: 4% Paraformaldehyde Permeabilization: 0.1% TritonX-100 Primary ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60444R

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