Product Name	FYN
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	A11F5
React Species	(predicted: Human, )
Applications	WB=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	非受体酪氨酸蛋白激酶在许多生物学过程中发挥作用，包括调节细胞生长和存活、细胞粘附、整合素介导的信号传导、Cytoskeleton重塑、细胞运动、免疫反应和轴突引导。非活性FYN在催化结构域内的C末端磷酸化。在PKA激活后，该蛋白随后与PTK2/FAK1结合，允许PTK2/FAK1磷酸化、激活并靶向于局灶性粘连。通过CTNNB1（β连环蛋白）和CTNND1（δ连环蛋白）的磷酸化参与细胞粘附和运动的调节。通过磷酸化包括肌动蛋白调节因子WAS和微管相关蛋白MAP2和MAPT在内的多种蛋白质来调节Cytoskeleton重塑。通过磷酸化AGAP2/PIKE-A并防止其凋亡分裂促进细胞存活。通过磷酸化包括NPHS1、KIRREL1和TRPC6在内的多种缝隙隔膜成分，参与调节肾小球缝隙隔膜（肾脏肾小球滤过器的重要部分）完整性的Signal transduction途径。

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