Product Name	G3BP1
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	H9B1
React Species	Human
Applications	WB=1:500-2000,ICC/IF=1:50-200,Flow-Cyt=1:50-100 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	在先天免疫中起重要作用的ATP和镁依赖性解旋酶。通过促进cGAS的DNA结合和激活，参与DNA触发的cGAS/STING通路。可能通过帮助DDX58检测致病性RNA来增强DDX58诱导的I型Interferon的产生。此外，在应力颗粒的形成中起着至关重要的作用。优先展开部分DNA和RNA双链体，其退火部分为17bp，在5’-和3’-端有一个悬挂的3’尾或悬挂的尾。以相当的效率解开DNA/DNA、RNA/DNA和RNA/RNA底物。通过沿着结合的单链DNA在5'到3'方向上移动而单向作用。体外磷酸化依赖序列特异性内啡肽酶。仅在胞嘧啶和腺嘌呤之间切割，优先在3'-UTR处切割MYC mRNA。
Product Picture	Cell line: HeLa Fixative: 100% Ice-cold methanol Permeabilization: 0.1% TritonX-100 Primary Ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary Ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60465M

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