Product Name	MPP8
Chinese Name
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	H12G4
React Species	Mouse
Applications	WB=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	异染色质组分，特异性识别和结合组蛋白H3（H3K9me）的甲基化“Lys-9”，并促进介导表观遗传抑制的蛋白质的募集。介导HUSH复合体向H3K9me3位点的募集：HUSH复合体被募集到富含H3K9me3的基因组位点，并且需要通过促进SETDB1（一种介导H3K9me3进一步沉积的组蛋白甲基转移酶）以及MORC2的募集来维持转录沉默。结合H3K9me并通过招募DNMT3A到靶CpG位点来促进DNA甲基化；它们可以位于基因的编码区内。介导CDH1表达下调。同时与MORC2和SETDB1协同抑制L1逆转录转座子，沉默依赖于抑制性表观遗传修饰，如H3K9me3标记。沉默事件通常发生在转录活跃基因的内含子内，导致宿主基因表达下调。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: room temperature 2h Secondary ab: Goat Anti-Mouse IgG H&L (HRP) Lysate: 1: MEF, 2: Mouse E12 brain, 3: 4T1, 4: F9 Protein loading quantity: 20 μg Exposure time: 30 s Predicted MW: 110 kDa Observed MW: 125 kDa

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