Product Name	EIF3L
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B5C12
React Species	Human(predicted:Mouse)
Applications	WB=1:2000-10000,ICC/IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2A/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	A component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is essential for several steps in the initiation of protein synthesis. The eIF-3 complex binds to the 40S ribosome and promotes the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S pre-initiation complex (43S-PIC). The eIF-3 complex stimulates the recruitment of mRNA to the 43S PIC and scans the mRNA for AUG recognition. The eIF-3 complex is also required for the disassembly and recycling of post-termination ribosomal complexes and subsequently prevents the premature joining of 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates the translation of a subset of mRNAs involved in cell proliferation, including cell cycle, differentiation, and apoptosis, and exerts translational activation or inhibition using different RNA stem-loop binding modes in the context of FCV infection, functioning in ribosomal termination-reinitiation events leading to VP2 translation.

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