Product Name	BAG6
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B5E6
React Species	Human,Mouse,Rat
Applications	WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Adenosine triphosphate (ATP)-independent molecular chaperones prevent misfolding and aggregation of hydrophobic protein plaques. The BAG6/BAT3 complex functions as part of the cytosolic protein quality control complex. It maintains these client proteins in a soluble state and is involved in their proper delivery to the endoplasmic reticulum or facilitates their sorting to the proteasome, where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. It is recruited to ribosomes, interacts with the transmembrane region of newly synthesized tail-anchored proteins, and mediates their delivery to the endoplasmic reticulum together with SGTA and ASNA1.

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