Product Name	PSMB8
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	H12B10
React Species	Human,Rat
Applications	WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The proteasome is a multicatalytic protease complex characterized by its ability to cleave peptides at Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group under neutral or slightly alkaline pH conditions. The proteasome possesses ATP-dependent proteolytic activity, and this subunit is involved in antigen processing to generate class I-binding peptides. Replacing PSMB5 with PSMB8 can enhance the ability of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. It is involved in the production of spliced peptides formed by the ligation of two separate proteasomal cleavage products that are not adjacent in the parent protein. It serves as a major component of interferon-γ-induced sensitivity. It plays a key role in apoptosis through the degradation of the apoptosis inhibitor MCL1. It may be involved in inflammatory response pathways. In cancer cells, the replacement of isoform 1 (E2) with isoform 2 (E1) leads to a deficiency of the immunoproteasome. It is essential for the differentiation of preadipocytes into adipocytes.

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