Product Name	SMYD2
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B10D2
React Species	Human(predicted:Rat)
Applications	WB=1:500-1000,ICC/IF=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	使组蛋白和非组蛋白（包括p53/TP53和RB1）甲基化的蛋白质赖氨酸N-甲基转移酶。体内特异性地三甲基化组蛋白H3'赖氨酸-4'（H3K4me3），这种活动需要与HSP90alpha相互作用。在p53/TP53上显示更高的甲基转移酶活性。一甲基化p53/TP53的Lys-370，导致p53/TP53的DNA结合活性和随后的转录调节活性降低。“Lys-860”处的RB1单甲基化物。
Product Picture	Cell line: HepG2 Fixative: 100% Ice-cold methanol Permeabilization: 0.1% Triton X-100 Primary Ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary Ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60487M

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