Product Name	VPS18
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	H3H6
React Species	Human,Rat(predicted:Mouse)
Applications	WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	Ig2A/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	It plays a role in vesicle-mediated protein transport to lysosomes, including endocytic membrane transport and autophagic pathways. It is considered a core component of the putative HOPS and CORVET endosomal tethering complexes, which are thought to be involved in Rab5 to Rab7 endosomal conversion, possibly involving MON1A/B, and to mediate tethering and docking events during SNARE-mediated membrane fusion by binding to SNAREs and SNARE complexes. The HOPS complex is proposed to be recruited to Rab7 on late endosomal membranes and regulate late endocytic, phagocytic, and autophagic transport to lysosomes. The CORVET complex is thought to be a Rab5 effector and may mediate early endosomal fusion in specific endosomal subpopulations. It is essential for the fusion of endosomes and autophagosomes with lysosomes. It is involved in the dendritic development of Purkinje cells.

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