Product Name	ALDH1L1
Chinese Name	乙醛脱氢酶1蛋白家族L1Recombinant rabbit monoclonal anti
Alias	AL1L1_HUMAN; Cytosolic 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase family 1 member L1; FTHFD; EC:1.5.1.6; 10-FTHFDH; FDH; 10-fTHF;
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	G10H7
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,ICC/IF=1:50-200,IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in liver, pancreas and kidney. SWISS: O75891 Gene ID: 10840 Database links: Entrez Gene: 10840 Human Entrez Gene: 107747 Mouse Entrez Gene: 64392 Rat SwissProt: O75891 Human SwissProt: Q8R0Y6 Mouse SwissProt: P28037 Rat 该基因编码的蛋白质催化10-甲酰四氢叶酸、烟酰胺腺嘌呤二核苷酸磷酸（NADP+）和水转化为四氢叶酸、NADPH和二氧化碳。编码的蛋白质属于乙醛脱氢酶家族。该基因的功能丧失或表达与Apoptosis减少、细胞活力增强和癌症进展有关。有一个反义转录物与这个基因位点在相反的链上重叠。选择性剪接导致多个转录变体。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:1000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: Human liver, 2: Mouse liver, 3: Mouse kidney, 4: Rat liver Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 100 kDa Observed MW: 110 kDa Tissue: Mouse liver Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100 Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: SP Kit(Rabbit) (sp-0023) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60542R Tissue: Human liver cancer Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:100 Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: SP Kit(Rabbit) (sp-0023) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60542R Cell line: HepG2 Fixative: 4% Paraformaldehyde Permeabilization: 0.1% TritonX-100 Primary ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60542R

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