Product Name	SUV39H1
Chinese Name	组蛋白H3 K9甲基转移酶Recombinant rabbit monoclonal anti
Alias	SUV91_HUMAN; Histone-lysine N-methyltransferase SUV39H1; KMT1A; UV39H; EC:2.1.1.355; Histone H3-K9 methyltransferase 1 (H3-K9-HMTase 1); Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Suppressor of variegation 3-9 homolog 1 (Su(var)3-9 homolog 1); SUV39H1 histone lysine methyltransferase; MG44; SUV39H; H3-K9-HMTase 1;
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	E2B10
React Species	Human,Mouse
Applications	WB=1:200-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] SWISS: O43463 Gene ID: 6839 组蛋白甲基转移酶，以单乙基化H3‘Lys-9’为底物，特异性地对组蛋白H3的‘Lys-9’进行三甲基化。也有弱甲基化组蛋白H1（体外）。H3‘Lys-9’三甲基化通过向甲基化组蛋白中招募HP1（CBX1、CBX3和/或CBX5）蛋白，代表表观遗传转录抑制的一个特定标记。主要作用于异铬酸盐区，在周中心区和端粒区的本构性异染色质的建立中起着重要作用。H3'Lys-9'三甲基化也需要在中心周重复点直接DNA甲基化。SUV39H1通过与RB1相互作用而以组蛋白H3为靶点，参与了抑制肌D1刺激分化、调控细胞周期退出和进入分化的控制开关、PML-RARA融合蛋白的抑制、BMP诱导的抑制等过程，抑制IgA的开关重组和端粒长度的调节。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:1000 Primary ab incubation condition: 2 hours at room temperature Secondary ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: HeLa, A431, 3T3 Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 48 kDa Observed MW: 48 kDa

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