Product Name	IDH1
Chinese Name	异柠檬酸脱氢酶1单克隆抗体
Alias	IDHC_HUMAN; Isocitrate dehydrogenase [NADP] cytoplasmic; PICD; EC:1.1.1.42; IDH; Cytosolic NADP-isocitrate dehydrogenase; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; IDP; IDCD; HEL-216; HEL-S-26;
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	C5A6
React Species	Human,Rat
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:50-200,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	46kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] Subcellular Location: Cytoplasm. Peroxisome. SWISS: O75874 Gene ID: 3417 Database links: Entrez Gene: 3417 Human SwissProt: O75874 Human IDH1, also known as PICD and IDP, belongs to the isocitrate dehydrogenase and isopropylmalate dehydrogenase families. This is a common feature of major subtypes of human primary brain cancers. Genetic variations are associated with cartilaginous tumours such as enchondromas or chondrosarcomas. Mutations of Arg-132 to Cys, Gly, or His eliminate the conversion of isocitrate to α-ketoglutarate. Instead, α-ketoglutarate is converted to R(-)-2-hydroxyglutarate.

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