Product Name	CFTR C-terminus
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	E11H3
React Species	Human
Applications	IHC-P=1: 50-200,IHC-F=1: 50-200,IF=1: 50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2A/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	上皮离子通道在调节上皮离子、水转运和体液稳态中起重要作用。介导氯离子穿过The cell membrane的运输。通道活性与ATP水解相耦合。离子通道对HCO（3-）也具有渗透性，选择性取决于细胞外氯化物浓度。通过调节其他离子通道和转运体的活性来发挥其功能。在气道液体稳态中起重要作用。有助于调节气道表面液体层的pH值和离子含量，从而在防御病原体方面发挥重要作用。调节上皮钠通道（ENaC）复合物的活性，部分通过调节ENaC复合物的细胞表面表达。抑制含有亚单位SCNN1A、SCNN1B和SCNN1G的ENaC通道的活性。抑制包含亚单位SCNN1D、SCNN1B和SCNN1G的ENaC通道的活性，但不抑制包含亚单位SCNN1A、SCNN1B和SCNN1G的ENaC通道的活性。可能通过调节转运体SLC4A7来调节epithelial cells碳酸氢盐的分泌和挽救。能抑制ANO1的氯离子通道活性。
Product Picture	Tissue: Human placenta Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:100 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Mouse)(sp-0024) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60568M

Cartpieces

• 
• 9

  9Delete

• 
• 5

  5Delete

• 
• S

  SDelete

• 
• M

  MDelete

• 
• +

  +Delete

• 
• 1

  1Delete

• Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 5

  5Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• Delete

• Delete

• 

• Delete

• 
• i

  iDelete

• 
• i

  iDelete

• Delete

• 
• 1

  1Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• Delete

• 
• 2

  2Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• Delete

• 
• -

  -Delete

• 
• -

  -Delete

• 
• 0

  0Delete

• Delete

• 
• t

  tDelete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• f

  fDelete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• 
• 5

  5Delete

• 
• $

  $Delete

• Delete

• 
• 0

  0Delete

• Delete

• Delete

• Delete

• 
• M

  MDelete

• 
• 5

  5Delete

• 
• A

  ADelete

Totalgoods,subtotals:￥Checkout