Product Name	TG
Chinese Name	甲状腺球蛋白Recombinant rabbit monoclonal anti
Alias	THYG_HUMAN; Thyroglobulin; AITD 3; AITD3; hTG; TDH3; Tgn;
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	A7B9
React Species	Human,Mouse,Rat
Applications	IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200,WB=1:500-2000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	660kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009] SWISS: P01266 Gene ID: 7038 Database links: Entrez Gene: 7038 Human SwissProt: P01266 Human 用作生产碘化甲状腺激素甲状腺素（T4）和三碘甲状腺素（T3）的底物。 T3和T4的合成涉及对TG /甲状腺球蛋白的选定酪氨酸残基加碘，然后在甲状腺滤泡内腔中进行氧化偶联。 在TG重新内在化和溶酶体介导的蛋白水解之后，T3和T4从多肽主链释放，导致它们分泌到血液中。 一个二聚体产生7个甲状腺激素分子。
Product Picture	Tissue: Human thyroid Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:1000 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Rabbit) (sp-0023) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60597R Tissue: Human thyroid cancer Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:100 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Rabbit) (sp-0023) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60597R Cell line: TT Fixation: 4% Paraformaldehyde Permeabilization: 90% Methanol Primary Ab dilution: 1:100 Secondary Ab: Goat anti Rabbit IgG Unlabelled control: The cell without incubation with primary antibody and secondary antibody (Black line). Isotype control: Rabbit monoclonal IgG (Blue line). Comment: Line red is the positive signal for SLM-60597R

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