Product Name	Recombinant Rabbit Anti-CDKN2B Monoclonal Antibody
Cat No.	SLA0774M
Alias	CDK4I; INK4B; MTS2; P15; TP15; p15INK4b; p15(INK4b); CDN2B_HUMAN; CDKN2B; Multiple tumor suppressor 2 (MTS-2); p14-INK4b; p15-INK4b (p15INK4B); CDN2B_MOUSE; p15-INK4b; CDN2B_RAT; Ink4; cyclin dependent kinase inhibitor 2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Host Species	Mouse
Isotype	IgG
Clonality	Monoclonal
Clone No.	1C7
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Synthesized peptide derived from human p15 INK (PTR2192)
Purification	affinity purified by Protein G
Concentration	1mg/ml
Predicted MW.	15 kDa
Swiss-Prot	P42772
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	cyclin dependent kinase inhibitor 2B (CDKN2B) Homo sapiens This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor , which forms a complex with CDK4 or CDK6 , and prevents the activation of the CDK kinases , thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta , which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene , which encode distinct proteins , have been reported. [provided by RefSeq , Jul 2008]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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