Product Name	Recombinant Rabbit Anti-CDKN2A Monoclonal Antibody
Cat No.	SLA0773M
Alias	ARF; CAI2; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16; ARF-INK4a; INK4a-ARF; Ink4a/Arf; Pctr1; p16(INK4a); p19; p16Cdkn2a; CDN2A_HUMAN; CDKN2A; Cyclin-dependent kinase 4 inhibitor A (CDK4I); Multiple tumor suppressor 1 (MTS-1); p16-INK4a (p16-INK4 | p16INK4A); CDN2A_MOUSE; p16-INK4a (p16-INK4); CDN2A_RAT; p16-INK4a (p16 | p16-INK4);
Host Species	Mouse
Isotype	IgG2b/Kappa
Clonality	Monoclonal
Clone No.	4E10
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Synthesized peptide derived from human p16 INK
Purification	affinity purified by Protein G
Concentration	1mg/ml
Predicted MW.	17 kDa
Swiss-Prot	P42771
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported , two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with , and sequester , the E3 ubiquitin-protein ligase MDM2 , a protein responsible for the degradation of p53. In spite of the structural and functional differences , the CDK inhibitor isoforms and the ARF product encoded by this gene , through the regulatory roles of CDK4 and p53 in cell cycle G1 progression , share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors , and is known to be an important tumor suppressor gene. [provided by RefSeq , Sep 2012]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.