Product Name	Recombinant Rabbit Anti-PIK3CA Monoclonal Antibody
Cat No.	SLA0772M
Alias	CCM4; CLAPO; CLOVE; CWS5; HMH; MCAP; MCM; MCMTC; PI3K; PI3K-alpha; p110-alpha; PK3CA_HUMAN; PIK3CA; PI3-kinase subunit alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha (PtdIns-3-kinase subunit p110-alpha | p110alpha); Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; 2.7.1.137; 2.7.1.153; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; phosphoinositide-3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Host Species	Mouse
Isotype	IgG2b/Kappa
Clonality	Monoclonal
Clone No.	8H1
React Species	Human
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Synthesized peptide derived from human PIK3CA H1047R
Purification	affinity purified by Protein G
Concentration	1mg/ml
Predicted MW.	124 kDa
Swiss-Prot	P42336
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The PIK3CA gene is located at 3Q26.3 and encodes a 124 kDa protein. The protein is composed of 85 kDa regulatory subunit and 110 kDa catalytic subunit. The most common mutations of PIK3CA occur in exon 9 and exon 20. H1047R , one of the most common mutations occurs in exon 20. PIK3CA plays an important role in the PI3K/AKT/mTOR signaling pathway , which can be activated by this mutation , closely related to the occurrence of tumors and disease progression. In non-small cell lung cancer , H1047R mutantion can phosphorylate Akt and activate downstream pathways to promote the survival and expansion of tumor cells.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.