Product Name	Rabbit Anti-BCL2L1 Polyclonal Antibody
Cat No.	SLA0108
Chinese Name	Bcl-xL蛋白抗体
Alias	BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52; Bcl(X)L; Bcl-XL; bcl2-L-1; B2CL1_HUMAN; BCL2L1; Apoptosis regulator Bcl-X; B2CL1_MOUSE; B2CL1_RAT; Blc2l; BCL2 like 1; protein phosphatase 1, regulatory subunit 52
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from the human Bcl-xL
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	26 kDa
Gene ID	598
Swiss-Prot	Q07817
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	bs-1336P is one synthetic peptide derived from human Bcl-xL. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Bcl-xL Polyclonal Antibody, Unconjugated (SLA0108) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.	Figure 2. Paraformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Bcl-xL Polyclonal Antibody, Unconjugated (SLA0108) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.
Figure 3. Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with Bcl-xL Polyclonal Antibody, Unconjugated (SLA0108) at 1:200 overnight at 4°C, followed by conjugation to the SL0295G-HRP and DAB (C-0010) staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.