Product Name	Recombinant Rabbit Anti-FCGR3A Monoclonal Antibody
Cat No.	SLA0594M
Chinese Name	FC段γ受体3/免疫球蛋白G Fc段受体III单克隆抗体
Alias	CD16; CD16-II; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; FcGRIIIA; IGFR3; IMD20; CD16-2; Fcgr4; FCG3A_HUMAN; FCGR3A; IgG Fc receptor III-A; CD16a antigen; Fc-gamma RIII-alpha (Fc-gamma RIII | Fc-gamma RIIIa | FcRIII | FcRIIIa | FcgammaRIIIA); IgG Fc receptor III-2; FCGR3_MOUSE; IgG Fc receptor III; Fc-gamma RIII (FcRIII); FCGR3_RAT; Fc gamma receptor IIIa; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG receptor IIIa; FcγR III;
Host Species	Mouse
Isotype	IgG
Clonality	Monoclonal
Clone No.	7A10
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human Fc gamma RIIIA/CD16a (F176) Protein
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	27 kDa
Subcellular Location	Membrane
Gene ID	2214
Swiss-Prot	P08637
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Human cervical cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD16A Monoclonal Antibody, Unconjugated (SLA0594M) at 1:200 overnight at 4°C, followed by conjugation to the SL40296G-HRP and DAB (C-0010) staining.	Figure 2. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD16A Monoclonal Antibody, Unconjugated (SLA0594M) at 1:200 overnight at 4°C, followed by conjugation to the SL40296G-HRP and DAB (C-0010) staining.
Figure 3. Paraformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with CD16A Monoclonal Antibody, Unconjugated (SLA0594M) at 1:200 overnight at 4°C, followed by conjugation to the SL40296G-HRP and DAB (C-0010) staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

Ordering & shipping

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