Product Name	ABCA3/P180 Lamellar Body Protein
Chinese Name	三磷酸腺苷结合盒转运体3抗体
Alias	ABC 3; ABC C; ABC C transporter; ABC transporter 3; ABC-C transporter; ABC3; ABCA 3; Abca3; ABCA3 protein; ABCA3_HUMAN; ABCC; ATP binding cassette 3; ATP binding cassette sub family A (ABC1) member 3; ATP binding cassette sub family A member 3; ATP binding cassette transporter 3; ATP-binding cassette 3; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; CED7. C. elegans, homolog of; EST111653; LBM 180; LBM180; MGC72201; SMDP3.
literatures	Specific References (1) | SL17588R has been referenced in 1 publications. [IF=3.098] Mingxing Fang. et al. SOX11 and FAK participate in the stretch‑induced mechanical injury to alveolar type 2 epithelial cells. Int J Mol Med. 2021 Jan;47(1):361-373 IF ; Mouse. PubMed:33236128
Research Area	Tumour Cell biology Signal transduction Transporter Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
Applications	IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	191kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ABCA3/P180 Lamellar Body Protein: 65-160/1704
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008] Function: Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. Subcellular Location: Membrane. Tissue Specificity: Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma. DISEASE: Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Similarity: Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. SWISS: Q99758 Gene ID: 21 Database links: Entrez Gene: 21 Human Entrez Gene: 27410 Mouse Entrez Gene: 302973 Rat Omim: 601615 Human SwissProt: Q99758 Human SwissProt: Q8R420 Mouse Unigene: 26630 Human Unigene: 239470 Mouse Unigene: 233424 Rat

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