Product Name	PIGR
Chinese Name	多聚免疫球蛋白受体抗体
Alias	Hepatocellular carcinoma associated protein TB6; Phosphatidylinositol glycan, class R; PIgR; Poly Ig receptor; Polymeric immunoglobulin receptor; PIGR_HUMAN.
literatures	Specific References (1) | SL6061R has been referenced in 1 publications. [IF=2.323] Bin Zeng. et al. Porcine Milk-Derived Small Extracellular Vesicles Promote Intestinal Immunoglobulin Production through pIgR. Animals-Basel. 2021 Jun;11(6):1522 WB ; Mouse. PubMed:34073819
Research Area	Cell biology immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, (predicted: Mouse, Rat, Dog, Cow, )
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PIGR: 31-130/764 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009] Function: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Secretory component: Secreted. Post-translational modifications: N-glycosylation is not necessary for Ig binding. Similarity: Contains 5 Ig-like V-type (immunoglobulin-like) SWISS: P01833 Gene ID: 5284 Database links: Entrez Gene: 5284 Human Entrez Gene: 18703 Mouse Omim: 173880 Human SwissProt: P01833 Human SwissProt: O70570 Mouse Unigene: 497589 Human Unigene: 276414 Mouse 多聚免疫球蛋白受体（pIgR）属Ⅰ型跨膜glycoprotein，可与多聚免疫球蛋白A和多聚免疫球蛋白M特异性结合，通过穿胞转运，将它们从epithelial cells基底侧膜转运到顶膜，并最终分泌到外分泌液中去. 在此过程中，多聚免疫球蛋白受体的细胞外段被水解，释放出与多聚免疫球蛋白A或多聚免疫球蛋白M相结合的细胞外段（又称为分泌成分）. 分泌成分是sIgA分子的重要组成部分，直接参与sIgA的粘膜防御功能，而且在被动粘膜免疫中也有重要作用. 多聚免疫球蛋白受体通过介导细胞内多聚免疫球蛋白的转运，可以在粘膜的腔面阻止病原体粘附，在epithelial cells内中和病毒，也可以将固有层内的抗原分泌出去.
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug Primary: Anti-PIGR (SL6061R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 81 kD Observed band size: 131 kD Sample: 293T(Human) Cell Lysate at 30 ug Primary: Anti-PIGR (SL6061R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 81 kD Observed band size: 131 kD Paraformaldehyde-fixed, paraffin embedded (Human hepatocellular carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PIGR) Polyclonal Antibody, Unconjugated (SL6061R) at 1:200 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minu Blank control : 293T Cells (Blue line) Isotype control: SL0295P-AF647 (Orange line) Primary antibody: SL6061R-AF647 (Green line) COncentration: 2μg/10^6 cells,4℃ incubate 30min.

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