Product Name	phospho-Proteasome 20S alpha 3(Ser250)
Chinese Name	磷酸化蛋白酶体PSMα3抗体
Alias	Proteasome 20S alpha 3 (phospho S250); 20S Proteasome α3; HC8; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome (prosome macropain) subunit alpha type 3; Proteasome alpha 3 subunit; Proteasome component C8; Proteasome subunit alpha type 3; Proteasome subunit alpha type-3; Proteasome subunit C8; PSA3_HUMAN; PSC3; PSMA3.
literatures	Specific References  (2)     |     SL9353R has been referenced in 2 publications. [IF=3.998] Yu-lin Huang. et al. Novel targets identified by integrated proteomic and phosphoproteomic analysis in spermatogenesis of swamp buffalo ( Bubalus bubalis ). Sci Rep-Uk. 2020 Sep;10(1):1-11  WB,IHC ;  Bubalus bubalis.   PubMed:32973212 [IF=2.823] Peng‐fei Zhang. et al. Integrated analysis of phosphoproteome and ubiquitylome in epididymal sperm of buffalo (Bubalus bubalis). Mol Reprod Dev. 2021 Jan;88(1):15-33  IF ;  Bovine.   PubMed:33140506
Product Type	Phosphorylated anti
Research Area	Cell biology  Cyclin  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	28kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated Synthesised phosphopeptide derived from human Proteasome 20S alpha 3 around the phosphorylation site of Ser250: DE(p-S)DD
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with AURKB. Interacts with CDKN1A. Interacts with HIV-1 TAT protein. Interacts with hepatitis C virus (HCV) F protein. Interacts with Epstein-Barr virus EBNA3 proteins. Interacts with MDM2 and RB1. Interacts with the C-terminus of TBXA2R isoform 2. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the peptidase T1A family. SWISS: P25788 Gene ID: 5684 Database links: Entrez Gene: 5684 Human Entrez Gene: 19167 Mouse Entrez Gene: 29670 Rat Entrez Gene: 408248 Rat Omim: 176843 Human SwissProt: P25788 Human SwissProt: O70435 Mouse SwissProt: P18422 Rat Unigene: 558799 Human Unigene: 296338 Mouse Unigene: 3997 Rat

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