Product Name	RNF4
Chinese Name	RNF4单克隆抗体
Alias	RNF4_HUMAN; E3 ubiquitin ligase RNF4; E3 ubiquitin protein ligase RNF4; Protein SNURF; RES4 26; RING finger protein 4; SLX5; Small nuclear ring finger protein; SNURF.
Research Area	Chromatin and nuclear signals Epigenetics Ubiquitin
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	E4R2
React Species	Human,
Applications	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human RNF4.
Lsotype	IgG1,κ
Purification	affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010] Function: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Subcellular Location: Cytoplasm. Nucleus. Nucleus. PML body. Nucleus. nucleoplasm. Tissue Specificity: Widely expressed at low levels in many tissues; highly expressed in testis. Post-translational modifications: Sumoylated; conjugated by one or two SUMO1 moieties. Autoubiquitinated. Similarity: Contains 1 RING-type zinc finger. SWISS: P78317 Gene ID: 6047 Database links: Entrez Gene: 51573 Human Omim: 605943 Human SwissProt: Q9NZC3 Human Unigene: 512607 Human
Product Picture	Sample: Lane 1: LNCap cell lysates Lane 2: PC-3 cell lysates Lane 3: Human testis tissue lysates Primary: Anti-RNF4 (SLM-51716M) at 1/2000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 21 kD Observed band size: 34 kD

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