Product Name	STRAP
Chinese Name	丝氨酸/苏氨酸激酶受体相关蛋白单克隆抗体
Alias	MAP activator with WD repeats; MAWD; PTWD; serine/threonine kinase receptor associated protein; STRAP; UNR-interacting protein; UNRIP; WD 40 repeat protein PT WD; STRAP_HUMAN.
Research Area	Tumour immunology Chromatin and nuclear signals transcriptional regulatory factor Kinases and Phosphatases
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	F5B7
React Species	Human
Applications	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:50-200,IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022] SWISS: Q9Y3F4 Gene ID: 11171 SMN复合物在小核核糖核蛋白（snRNPs）的组装中起催化作用，snRNPs是剪接体的组成部分。因此，在细胞前mRNAs的拼接中起着重要的作用。大多数剪接体snRNP包含一组共同的Sm蛋白质SNRPB、SNRPD1、SNRPD2、SNRPD3、SNRPE、SNRPF和SNRPG，它们在小核RNA的Sm位点上组装成七聚体蛋白环，形成核心snRNP。在细胞质中，Sm蛋白SNRPD1、SNRPD2、SNRPE、SNRPF和SNRPG被控制核心snRNP组装的伴侣CLNS1A捕获在非活性的6S pICln Sm复合物中。CLNS1A的SMN复合物从捕获的Sm蛋白中解离并将其转移到SMN-Sm复合物触发核心snRNPs的组装并将其转运到The nucleus。条带在SMN复合体的细胞分布中起作用。负调节TGF-β信号，但通过增强其自身磷酸化和显著减少PDPK1与14-3-3蛋白的结合来正调节PDPK1激酶活性。
Product Picture	Blocking buffer: 5% NFDM/TBST Primary ab dilution: 1:5000 Primary ab incubation condition: room temperature 2h Secondary ab: Goat Anti-Mouse IgG H&L (HRP) Lysate: 1: HeLa, 2: 293 Protein loading quantity: 20 μg Exposure time: 30 s Predicted MW: 38 kDa Observed MW: 38 kDa Tissue: Human-lung-squamous-carcinoma Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:100 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Mouse)(sp-0024) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60469M Tissue: Human colon Section type: Formalin fixed & Paraffin -embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:100 Primary ab incubation condition: 1 hour at room temperature Secondary ab: SP Kit(Mouse)(sp-0024) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for SLM-60469M Cell line: HeLa Fixative: 4% Paraformaldehyde Permeabilization: 0.1% TritonX-100 Primary ab dilution: 1:50 Primary incubation condition: 4°C overnight Secondary ab: Goat Anti-Rabbit IgG Nuclear counter stain: DAPI (Blue) Comment: Color green is the positive signal for SLM-60469M

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