Product Name	PKN1
Chinese Name
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	F3A4
React Species	(predicted: Human, Mouse, )
Applications	WB=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PKC相关的丝氨酸/苏氨酸蛋白激酶参与肌动蛋白骨架中间丝的调控、细胞迁移、Tumour细胞侵袭和转录调控等过程。信号级联的一部分，开始于肾上腺素能受体ADRA1B的激活并导致MAPK14的激活。通过磷酸化蛋白质如VIM和神经丝蛋白NEFH、NEFL和NEFM来调节Cytoskeleton网络，从而抑制它们的聚合。磷酸化MAPT/Tau的‘Ser-575’、‘Ser-637’和‘Ser-669’，降低其与微管结合的能力，导致微管蛋白组装的破坏。作为雄激素受体（ANDR）依赖性转录的关键辅活化子，通过被招募到ANDR靶基因并特异性介导组蛋白H3（H3T11ph）的“Thr-11”的磷酸化，这是一种表观遗传转录激活的特异性标记，通过KDM4C/JMJD2C促进组蛋白H3“Lys-9”（H3K9me）的去甲基化。磷酸化HDAC5、HDAC7和HDAC9，导致其在The nucleus中的输入受损。

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