Product Name	SIX2
Chinese Name
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	F9A1
React Species	(predicted: Human, )
Applications	WB=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2B/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	在肾脏、颅骨和胃等器官发育中起重要作用的转录因子。在肾脏发育过程中，通过对抗输尿管芽发出的诱导信号，维持帽间充质多能肾原祖细胞处于未分化状态，并与WNT9B协同促进再生祖细胞增殖。通过与TCF7L2和OSR1的相互作用，以一种典型的Wnt信号独立的方式阻止cap间充质中分化基因的转录，如WNT4。也独立于OSR1激活许多cap间充质基因的表达，包括自身、GDNF和OSR1。在颅面发育过程中，通过调节软骨细胞的分化，对颅底的生长和延长起作用。在胃器官发生过程中，通过调节包括NKX2-5、BMPR1B、BMP4、SOX9和GREM1在内的基因网络来控制幽门括约肌的形成和粘膜的生长。在鳃弓发育过程中，它介导HOXA2对胰岛素样生长因子途径的调控。也可能参与肢体肌腱和韧带的发育。

Cartpieces

• 
• 9

  9Delete

• 
• 5

  5Delete

• 
• S

  SDelete

• 
• M

  MDelete

• 
• +

  +Delete

• 
• 1

  1Delete

• Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 5

  5Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• Delete

• Delete

• 

• Delete

• 
• i

  iDelete

• 
• i

  iDelete

• Delete

• 
• 1

  1Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• Delete

• 
• 2

  2Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• Delete

• 
• -

  -Delete

• 
• -

  -Delete

• 
• 0

  0Delete

• Delete

• 
• t

  tDelete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• f

  fDelete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• 
• 5

  5Delete

• 
• $

  $Delete

• Delete

• 
• 0

  0Delete

• Delete

• Delete

• Delete

• 
• M

  MDelete

• 
• 5

  5Delete

• 
• A

  ADelete

Totalgoods,subtotals:￥Checkout