Product Name	COPS3
Chinese Name
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	B11F9
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,ICC/IF=1:50-200,IF=1:50-200,Flow-Cyt=1:50-100（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	COP9信号体复合物（CSN）的组成部分，该复合物参与各种细胞和发育过程。CSN复合物是Ubiquitin（Ubl）缀合途径的重要调节剂，其通过介导SCF型E3连接酶复合物的cullin亚基的去腺苷酸化，导致SCF型复合物如SCF，CSA或DDB2的Ubl连接酶活性降低。该复合物还可能通过其与CK2和PKD激酶的结合参与p53/TP53，c-jun/jun，IkappaBalpha/NFKBIA，ITPK1和IRF8/ICSBP的磷酸化。TP53和JUN的CSN依赖性磷酸化分别促进和保护Ubl系统的降解。

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