Product Name	RAG2
Chinese Name
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	C5E7
React Species	(predicted: Human, Mouse, )
Applications	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	RAG复合物的核心成分，是一种多蛋白复合物，在V（D）J重组过程中介导DNA切割阶段。V（D）J重组通过重组不同的V（变量），在某些情况下D（多样性）和J（连接）基因片段，在发育中的Blymphocyte和Tlymphocyte中组装了多种免疫球蛋白和T细胞受体基因。RAG复合物对DNA的切割分两步进行：在七聚体上游的顶部链中引入第一个缺口，产生一个3'-羟基，可在直接酯交换反应中攻击对侧链上的磷酸二酯键，从而产生4个DNA末端：2个发夹编码末端和2个钝头，5'-磷酸化末端。染色质结构在V（D）J重组反应中起着重要作用，组蛋白H3在Lys-4（H3K4me3）上的三甲基化刺激了刻痕和海pinning步骤。

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