Product Name	PCCB
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B10B10
React Species	Human,Mouse,Rat
Applications	WB=1:500-2000,IHC-P=1:50-200,IHC-F=1:50-200,IF=1:50-200（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG2A/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This is one of the two subunits of biotin-dependent propionyl-CoA carboxylase (PCC), which is a mitochondrial enzyme involved in the catabolism of odd-chain fatty acids, branched-chain amino acids such as isoleucine, threonine, methionine, valine, and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA. In the holoenzyme, the α subunit catalyzes the ATP-dependent carboxylation of biotin carried by the biotin carboxyl carrier (BCC) domain, while the β subunit subsequently transfers the carboxyl group from carboxylated biotin to propionyl-CoA. Propionyl-CoA carboxylase also acts significantly on butyryl-CoA, converting it to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a lower rate. Other alternative minor substrates include (2E)-butenoyl-CoA/crotonyl-CoA.

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