Product Name	NUDT21
Chinese Name	剪切和多聚腺苷酸化特异性因子5单克隆抗体
Alias	CFIM 25; CFIM25; Cleavage and polyadenylation specific factor 5 25 kD subunit; Cleavage and polyadenylation specific factor 5 25 kDa; Cleavage and polyadenylation specific factor 5; Cleavage and polyadenylation specificity factor 25 kDa subunit; Cleavage and polyadenylation specificity factor subunit 5; Cleavage factor Im complex 25 kDa subunit; CPSF 25; CPSF 25 kDa subunit; CPSF 5; CPSF25; CPSF5; CPSF5_HUMAN; DKFZp686H1588; Nucleoside diphosphate linked moiety X motif 21; Nucleoside diphosphate-linked moiety X motif 21; Nudix (nucleoside diphosphate linked moiety X) type motif 21; Nudix motif 21; NUDT 21; Pre mRNA cleavage factor Im (25kD); Pre mRNA cleavage factor Im 25 kDa subunit; Pre mRNA cleavage factor Im 25kD subunit; Pre-mRNA cleavage factor Im 25 kDa subunit.
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	H8B8
React Species	Human,Mouse
Applications	WB=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:50-200,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008] SWISS: O43809 Gene ID: 11051 Database links: Entrez Gene: 11051 Human Entrez Gene: 68219 Mouse SwissProt: O43809 Human SwissProt: Q9CQF3 Mouse Components of the cleavage factor Im (CFIm) complex, acting as activators in the process of pre-mRNA 3' end cleavage and polyadenylation, are required for the maturation of pre-mRNA into functional mRNAs. CFIm helps recruit multi-protein complexes at specific sequences in the 3' end of pre-mRNA, known as cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, leading to alternative cleavage and polyadenylation (APA) that generates mRNAs with variable 3'-end formations. The CFIm complex serves as a key regulator in the selection of cleavage and polyadenylation sites during the APA process by binding to the 5'-UGUA-3' element in the 3'-untranslated region (UTR) of numerous pre-mRNAs. NUDT21/CPSF5 indirectly activates the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binding to the 5'-UGUA-3' element located upstream of the pA signal acts as an enhancer for pre-mRNA 3' end processing.

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