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Rabbit Anti-MYB  antibody
Rabbit Anti-MYB antibody
Avian myeloblastosis viral (v-myb) oncogene homolog; C myb; c-Myb; MYB_HUMAN; Proto-oncogene c-Myb; Transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog.
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  • NO.:SL25011R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep)
    Applications:IHC-P,IHC-F,IF
    concentration:1mg/ml
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Details

Product Name MYB
Chinese Name 转录激活因子MYB抗体
Alias Avian myeloblastosis viral (v-myb) oncogene homolog; C myb; c-Myb; MYB_HUMAN; Proto-oncogene c-Myb; Transcriptional activator Myb; v-myb avian myeloblastosis viral oncogene homolog.
Research Area Tumour immunology Chromatin and nuclear signals transcriptional regulatory factor Epigenetics
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep)
Applications IHC-P=1:400-800,IHC-F=1:400-800,IF=1:100-500(Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 84kDa
Cellular localization The nucleus
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human MYB : 231-330/640
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Function:
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Subcellular Location:
Nucleus.

Post-translational modifications:
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.

Similarity:
Contains 3 HTH myb-type DNA-binding domains.

SWISS:
P10242

Gene ID:
4602

Database links:

Entrez Gene: 317776 Cow

Entrez Gene: 4602 Human

Entrez Gene: 17863 Mouse

Entrez Gene: 498982 Rat

Omim: 189990 Human

SwissProt: P46200 Cow

SwissProt: P10242 Human

SwissProt: P06876 Mouse

Unigene: 606320 Human

Unigene: 52109 Mouse




Product Picture
Paraformaldehyde-fixed, paraffin embedded (rat colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MYB) Polyclonal Antibody, Unconjugated (SL25011R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human breast); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MYB) Polyclonal Antibody, Unconjugated (SL25011R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MYB) Polyclonal Antibody, Unconjugated (SL25011R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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