Product Name	Recombinant Rabbit Anti-IGF1R Monoclonal Antibody
Cat No.	SLA1066M
Chinese Name	胰岛素样生长因子I受体单克隆抗体
Alias	CD221; IGFIR; IGFR; JTK13; A330103N21Rik; D930020L01; IGF-1R; hyft; IGF-1 receptor; IGFIRC; Igfr1; IGF1R_HUMAN; IGF1R; Insulin-like growth factor I receptor (IGF-I receptor); 2.7.10.1; IGF1R_MOUSE; IGF1R_RAT; insulin like growth factor 1 receptor; insulin-like growth factor 1 receptor
Host Species	Mouse
Isotype	IgG1
Clonality	Monoclonal
Applications	WB (1:500-2000) IP (1:20-50) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant protein of human IGF1R
Purification	affinity purified by Protein A
Predicted MW.	150 kDa
Subcellular Location	Membrane
Gene ID	3480
Swiss-Prot	P08069
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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