Product Name	Recombinant Rabbit Anti-TSC1 Monoclonal Antibody
Cat No.	SLA0711M
Chinese Name	结节性硬化症蛋白1单克隆抗体
Alias	LAM; TSC; TSC1_HUMAN; TSC1; Tuberous sclerosis 1 protein; KIAA0243; TSC1_MOUSE; Tuberous sclerosis 1 protein homolog; TSC1_RAT; TSC complex subunit 1; tuberous sclerosis 1; hamartin
Host Species	Mouse
Isotype	IgG2b
Clonality	Monoclonal
Clone No.	K6F13
React Species	Mouse
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human TSC1 (Fragment) (His-tagged).
Purification	affinity purified by Protein G
Concentration	1mg/ml
Predicted MW.	130 kDa
Observed MW.	200 kDa
Subcellular Location	Cytoplasm
Gene ID	7248
Swiss-Prot	Q92574
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.