Product Name	Recombinant Rabbit Anti-MYH11 Monoclonal Antibody
Cat No.	SLA0330M
Chinese Name	人心肌肌凝蛋白(平滑肌) 小鼠单抗
Alias	AAT4; FAA4; SMHC; SMMHC; SMMS-1; VSCM2; SM1; SM2; MYH11_HUMAN; MYH11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; KIAA0866; MYH11_MOUSE; MYH11_RABIT; MYH11_RAT; myosin, heavy polypeptide 11, smooth muscle
Host Species	Mouse
Isotype	IgG1
Clonality	Monoclonal
React Species	Human,Mouse,Rat
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human Myosin C-terminus
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	200 kDa
Subcellular Location	Cytoplasm
Gene ID	4629
Swiss-Prot	P35749
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16[inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. It is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.

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