Product Name	KLHL2 Rabbit pAb
Cat No.	SL16767R
Chinese Name	Kelch样蛋白2抗体
Alias	ABP-KELCH; MAV; MAYVEN; KLHL2_HUMAN; KLHL2; Actin-binding protein Mayven; kelch like family member 2; kelch (Drosophila)-like 2 (Mayven); kelch-like 2, Mayven (Drosophila)
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
Clone No.
React Species	Human,Mouse
Applications	WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) ELISA (1:5000-10000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human KLHL2
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	66 kDa
Observed MW.	66 kDa
Subcellular Location	N/A
Gene ID	11275
Swiss-Prot	O95198
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	KLHL2 is a 593 amino acid actin-binding protein. Highly expressed in brain, KLHL2 is thought to play a role in the organization of the actin cytoskeleton in brain cells. KLHL3 (kelch-like protein 3), is a 587 amino acid protein active in the protein ubiquitination pathway. KLHL3 is thought to be a substrate-specific adapter of an E3 ubiquitin-ligase complex that mediates the ubiquitination of target proteins, which leads to proteasomal degradation of the target protein. KLHL2 and KLHL3 proteins contain six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.