Product Name	Recombinant Rabbit Anti-ABCC2 Monoclonal Antibody
Cat No.	SLA1201M
Chinese Name	多药耐药相关蛋白2重组兔单抗
Alias	ABC30; CMOAT; DJS; MRP2; cMRP; mrp; MRP2_HUMAN; ABCC2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2; 7.6.2.-; 7.6.2.2; 7.6.2.3; CMOAT1; MRP2_MOUSE; MRP2_RAT; ATP binding cassette subfamily C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	14F18
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Flow-Cyt (1ug/Test) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human ABCC2
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	174 kDa
Subcellular Location	Membrane
Gene ID	1244
Swiss-Prot	Q92887
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.