Product Name	Recombinant Rabbit Anti-P2RY6 Monoclonal Antibody
Cat No.	SLA0887M
Chinese Name	G蛋白偶联嘌呤受体p2y6重组兔单抗
Alias	P2Y6; P2Y6R; P2RY6_HUMAN; P2RY6; pyrimidinergic receptor P2Y6; pyrimidinergic receptor P2Y, G-protein coupled, 6
Host Species	Rabbit
Isotype	IgG
Clonality	Monoclonal
Clone No.	8H2
React Species	Human
Applications	WB (1:500-2000) Flow-Cyt (1:50-100) IP (1:20-50) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	A synthesized peptide derived from human P2Y6
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	36 kDa
Observed MW.	40 kDa
Subcellular Location	Membrane
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Nucleotides are emerging as important extracellular signaling molecules that mediate several effects, such as proliferation, differentiation, chemotaxis and cytokine release. The P2 receptor family is activated by the binding of nucleotides and is divided into two subfamilies, P2X and P2Y. The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The P2Y receptor family are G protein-coupled receptors which mediate the effects of extracellular nucleotides, primarily through the activation of phospholipase C. To some extent, the P2Y receptors can also activate potassium channels or, alternatively, inhibit adenylate cyclase and N-type calcium channels in response to extracellular nucleotides. The P2Y receptors are differentially expressed in several tissue types, such as heart, lung and brain. However, all P2Y receptors are expressed in leukocytes, which suggests a role for the P2Y receptor family in the activation of leukocytes and platelets in response to inflammation or vascular damage.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.