Product Name	Recombinant Rabbit Anti-CXCR3 Monoclonal Antibody
Cat No.	SLA0555M
Chinese Name	细胞表面趋化因子受体3（CD183）单克隆抗体
Alias	CXCR3_HUMAN; CXCR3; CXC-R3; CXCR-3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor (IP-10 receptor); GPR9; C-X-C motif chemokine receptor 3; chemokine (C-X-C motif) receptor 3
Host Species	Mouse
Clonality	Monoclonal
Clone No.	3C5
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	Recombinant human CXCR3 protein
Purification	affinity purified by Protein A
Predicted MW.	41 kDa
Observed MW.	48 kDa
Subcellular Location	Membrane
Gene ID	2833
Swiss-Prot	P49682
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. 25 ug total protein per lane of various lysates (see on figure) probed with CXCR3 monoclonal antibody, unconjugated (SLA0555M) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.