Product Name	Rabbit Anti-GFRA3 Polyclonal Antibody
Cat No.	SLA0007
Chinese Name	GDNF家族受体α3抗体 GFR α3
Alias	GDNFR3; GFRalpha3; GFRA3_HUMAN; GFRA3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3; GFRA3_MOUSE; GDNF family receptor alpha 3
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Mouse,Rat
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human GFR alpha 3
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	38 kDa
Observed MW.	42 kDa
Subcellular Location	Membrane
Gene ID	2676
Swiss-Prot	O60609
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF Beta superfamily of growth factors. Three receptors for these factors, GFR Alpha-1 (also designated GDNFR-Alpha, RETL1 or TrnR-1), GFR Alpha-2 (also designated GDNFR-Beta, RETL2, NTNR-Alpha or TrnR-2) and GFR Alpha-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFR Alpha-1 and GFR Alpha-2 have been shown to mediate the GDNF-dependent and NTN-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR Alpha-3 is expressed only during development.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Sample: Lane 1: Mouse Heart tissue lysates Lane 2: Mouse Stomach tissue lysates Lane 3: Rat Spleen tissue lysates Lane 4: Rat Stomach tissue lysates Primary: Anti-GFR alpha 3 (SLA0007) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 38 kDa Observed band size: 42 kDa

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.