Product Name	Rabbit Anti-KLF10 Polyclonal Antibody
Cat No.	SLA0029
Chinese Name	TGF-β诱导早期应答基因1抗体
Alias	EGR-alpha; EGRA; TIEG; TIEG1; EGR[a]; Egral; Gdnfif; TIEG-1; mGIF; KLF10_HUMAN; KLF10; Transforming growth factor-beta-inducible early growth response protein 1 (TGFB-inducible early growth response protein 1 | TIEG-1); KLF10_MOUSE; GDNF-inducible factor; Transcription factor GIF (mGIF); KLF10_RAT; Zinc finger transcription factor homolog CPG20; Cpg20; KLF transcription factor 10; TGFB inducible early growth response; Kruppel like factor 10; early growth response alpha
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	ICC/IF (1:50-200) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human TIEG1
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	53 kDa
Gene ID	7071
Swiss-Prot	Q13118
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	KLF10 is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5'-GGTGTG-3'. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (KLF10) polyclonal Antibody, Unconjugated (SLA0029) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.