Product Name	Rabbit Anti-AVP Polyclonal Antibody
Cat No.	SLA0038
Chinese Name	抗利尿激素/血管升压素/加压素/血管加压素抗体
Alias	ADH; ARVP; AVP-NPII; AVRP; VP; NEU2_HUMAN; AVP; arginine vasopressin; antidiuretic hormone; neurophysin II; diabetes insipidus; neurohypophyseal; prepro-AVP-NP II; prepro-arginine-vasopressin-neurophysin II; copeptin; argipressin
Host Species	Rabbit
Isotype	IgG
Clonality	Polyclonal
React Species	Human
Applications	WB (1:500-2000) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human Copeptin
Purification	affinity purified by Protein A
Concentration	1mg/ml
Predicted MW.	18 kDa
Observed MW.	18 kDa
Gene ID	551
Swiss-Prot	P01185
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Vasopressin, also known as arginine vasopressin (AVP) or antidiuretic hormone (ADH), is a posterior pituitary hormone that is synthesised in the hypothalamus. Vasopressin is synthesised as a precursor protein that consists of arginine vasopressin and two associated proteins, neurophysin 2 and the glycopeptide copeptin. Vasopressin, together with its carrier protein neurophysin II, is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. Vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney and also causes vasoconstriction of the peripheral vessels. Vasopressin can also contract smooth muscle during parturition and lactation. It also plays a role in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in the vasopressin precursor cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI), which is characterised by persistant thirst, polydipsia and polyuria.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Sample: Lane 1: Copeptin Active Peptide(SL21741P) Primary: Anti-Copeptin (SLA0038) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18 kDa Observed band size: 4 kDa

Figure 2. Sample: Lane 1: Recombinant human Vasopressin-neurophysin 2-copeptin protein (HEK293)(SL43179P) Primary: Anti-Copeptin (SLA0038) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 18 kDa Observed band size: 20 kDa

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.