Product Name	SNCA | alpha-Synuclein Mouse mAb
Cat No.	SLM-0968M
Chinese Name	核突触蛋白α单克隆抗体
Alias	NACP; PARK1; PARK4; PD1; alpha-Syn; alphaSYN; SYUA_HUMAN; SNCA; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor (NACP); SYUA_MOUSE; Syn; SYUA_RAT; synuclein alpha; Parkinson disease (autosomal dominant, Lewy body) 4; synuclein, alpha (non A4 component of amyloid precursor); non A4 component of amyloid precursor; alpha-synuclein; α-synuclein
Host Species	Mouse
Isotype	IgG
Clonality	Monoclonal
Clone No.	3D5
React Species	Human
Applications	IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
Immunogen	KLH conjugated synthetic peptide derived from human Alpha-Synuclein
Purification	affinity purified by Protein G
Concentration	1mg/ml
Subcellular Location	Nucleus
Gene ID	6622
Swiss-Prot	P37840
Storage	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016].
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

Validation Images

Figure 1. Paraformaldehyde-fixed, paraffin embedded Human Glioma; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Alpha-Synuclein Monoclonal Antibody, Unconjugated(SLM-0968M) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.	Figure 2. Paraformaldehyde-fixed, paraffin embedded Human Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Alpha-Synuclein Monoclonal Antibody, Unconjugated(SLM-0968M) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.
Figure 3. Paraformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Alpha-Synuclein Monoclonal Antibody, Unconjugated(SLM-0968M) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.	Figure 4. Paraformaldehyde-fixed, paraffin embedded Human Cerebellum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Alpha-Synuclein Monoclonal Antibody, Unconjugated(SLM-0968M) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Mouse, sp-0024) and DAB (C-0010) staining.

 

FOR RESEARCH USE ONLY. Not for use in diagnostic or therapeutic procedures.