Product Name	CD68
Chinese Name	CD68抗体
Alias	CD 68; CD68 antigen; CD68 molecule; DKFZp686M18236; GP110; Macrophage antigen CD68 (microsialin); macrosialin; SCARD1; Scavenger receptor class D member 1; macrosialin isoform A precursor; CD68_HUMAN; Macrosialin; Gp110; scavenger receptor class D, member 1; macrophage antigen CD68; LAMP4.
literatures	Specific References (7) | SL1432R has been referenced in 7 publications. [IF=6.208] Yongxin Guo. et al. Beneficial Effects of Oleosomes Fused with Human Fibroblast Growth Factor 1 on Wound Healing via the Promotion of Angiogenesis. INT J MOL SCI. 2022 Jan;23(21):13152 IHC, IF ; Rat. PubMed:36361940 [IF=4.932] Haoshen Feng. et al. Rosiglitazone ameliorated airway inflammation induced by cigarette smoke via inhibiting the M1 macrophage polarization by activating PPARγ and RXRα. Int Immunopharmacol. 2021 Aug;97:107809 IHC ; Rat. PubMed:34182323 [IF=3.99] Hu, Kaili, et al. "Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease." International journal of pharmaceutics 415.1 (2011): 273-283. IHC-P ; Mouse. PubMed:21651967 [IF=3.514] Zhang J et al. Role of selective blocking of bradykinin B1 receptor in attenuating immune liver injury in trichloroethylene-sensitized mice. Cytokine. 2018 Aug;108:71-81. IHC-P ; Mouse. PubMed:29579546 [IF=3.47] Ding L et al. Saponins of sea cucumber attenuate atherosclerosis in ApoE −/− mice via lipid-lowering and anti-inflammatory properties. Journal of Functional Foods,2018 48, 490–497. WB ; Rat&Mouse. PubMed:10.1016/j.jff.2018.07.046 [IF=3.32] Silva, Katie, et al. "Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders." Journal of NeuroVirology (2015): 1-12. IHC-P ; Human. PubMed:25636782 [IF=1.77] Lin, Li-Wen, et al. "Visfatin/pre-B cell colony-enhancing factor immunohistochemical overexpression in oral cancers." Journal of Applied Biomedicine (2014). IHC-P ; Human. PubMed:10.1016/j.jab.2014.08.003
Research Area	immunology Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human Mouse Rat
Applications	WB=1:500-2000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Detection molecular weight	110-140KDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD68: 1-130/354 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Human,Mouse,Rat1M TBS(pH7.4) with 1% BSA, Human,Mouse,Rat3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] Function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Subcellular Location: Isoform Short: Cell membrane; Single-pass type I membrane protein. Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. Post-translational modifications: N- and O-glycosylated Similarity: Belongs to the LAMP family. SWISS: P34810 Gene ID: 968 Database links: Entrez Gene: 968 Human Entrez Gene: 12514 Mouse Omim: 153634 Human SwissProt: P34810 Human SwissProt: P31996 Mouse Unigene: 647419 Human Unigene: 15819 Mouse 巨噬细胞Maker CD68为巨噬细胞抗原又称酸性溶霉菌glycoprotein，表达在单核、巨嗜、粒细胞和一些梭形细胞呈阳性表达。
Product Picture	Sample: Lane 1: A431 (Human) Cell Lysate at 30 ug Lane 2: A549 (Human) Cell Lysate at 30 ug Lane 3: Jurkat (Human) Cell Lysate at 30 ug Lane 4: Huvec (Human) Cell Lysate at 30 ug Primary: Anti-CD68 (SL1432R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 110/185-200 kD Observed band size: 110 kD Sample: Lane 1: Raw264.7 (Mouse) Cell Lysate at 30 ug Lane 2: Lymph node (Rat) Cell Lysate at 30 ug Primary: Anti-CD68 (SL1432R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 110/185-200 kD Observed band size: 110 kD Tissue/cell: human mammary cancer; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( Human,Mouse,Rat1M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CD68 Polyclonal Antibody, Unconjugated(SL1432R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining This image was generously provided by Amanda Brown, Ph.D. from Johns Hopkins University School of Medicine. Paraffin embedded human brain tissue labeled with Rabbit Anti-CD68 Polyclonal Antibody, Unconjugated (SL1432R) at 1:50 followed by conjugation to the secondary antibody and Permanent Fast Red Quanto staining

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