Product Name	OSCAR
Chinese Name	破骨细胞相关受体抗体
Alias	hOSCAR; hOSCARM2; hOSCARM3; mOSCAR; Oscar; Oscar protein; OSCAR_HUMAN; OSCARS1; OSCARS2; Osteoclast associated immunoglobulin like receptor; Osteoclast associated receptor; Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; PIgR-3; PIGR3; Poly Ig receptor 3; Poly-Ig receptor 3; Polymeric immunoglobulin receptor 3.
literatures	Specific References (2) | SL17523R has been referenced in 2 publications. [IF=3.448] Ma Q et al. Non‐coenzyme role of vitamin B1 in RANKL‐induced osteoclastogenesis and ovariectomy induced osteoporosis. J Cell Biochem. 2020 Feb 26. WB ; mouse. PubMed:32100911 [IF=3.266] Ma Q et al. Vitamin B5 inhibit RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation. Am J Transl Res. 2019 Aug 15;11(8):5008-5018. eCollection 2019. WB ; Mouse. PubMed:31497217
Research Area	Cell biology immunology Cell type markers t-lymphocyte b-lymphocyte Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	28kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human OSCAR: 51-150/282
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] Function: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Subcellular Location: Secreted and Cell membrane. Similarity: Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: Q8IYS5 Gene ID: 126014 Database links: Entrez Gene: 126014 Human Omim: 606862 Human SwissProt: Q8IYS5 Human Unigene: 347655 Human

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