Product Name	ACVR1B
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	A8B3
React Species	Human,Mouse
Applications	WB=1:500-1000,ICC/IF=1:100-500 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG/Kappa
Purification	Affinity purified by Protein A
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Transmembrane serine/threonine kinase activin type 1 receptor forms an activin receptor complex with activin type 2 receptors (ACVR2A or ACVR2B). It transmits activin signals from the cell surface to the cytoplasm, thereby regulating many physiological and pathological processes, including neuronal differentiation and survival, hair follicle development and cycling, pituitary FSH production, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. Activins are also thought to have paracrine or autocrine roles in ovarian follicle development. In the receptor complex, type 2 receptors (ACVR2A and/or ACVR2B) act as the primary activin receptors, while type 1 receptors (such as ACVR1B) function as downstream sensors of activin signaling. Activin binds to type 2 receptors on the plasma membrane and activates their serine/threonine kinases. The activated type 2 receptors then phosphorylate and activate type 1 receptors, such as ACVR1B. Once activated, the type 1 receptor binds to and phosphorylates the SMAD proteins SMAD2 and SMAD3 on their C-terminal serine residues. SMAD2 and SMAD3 are released into the cytoplasm shortly after binding to the activin receptor and subsequent phosphorylation, where they interact with the common partner SMAD4. This SMAD complex translocates to the nucleus, where it mediates activin-induced transcription. Inhibitory SMAD7 is recruited to ACVR1B via FKBP1A, which can prevent the binding of SMAD2 and SMAD3 to the activin receptor complex, thereby blocking activin signaling. Activin signal transduction is also antagonized by the binding of inhibin B to the receptor via the IGSF1 inhibin co-receptor. ACVR1B also phosphorylates TDP2.

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