Product Name	UGDH
Chinese Name	尿苷二磷酸葡萄糖脱氢酶单克隆抗体
Alias	UGDH_HUMAN; UDP-glucose 6-dehydrogenase; EC:1.1.1.22; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Uridine diphospho glucose dehydrogenase; UDP glucose 6 dehydrogenase; GDH; UGD; DEE84; EIEE84;
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	B6A9
React Species	Human(predicted:Mouse,Rat)
Applications	WB=1:1000-5000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:50-200,IF=1:100-500（Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The cell membrane Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
Lsotype	IgG1/Kappa
Purification	Affinity purified by Protein G
Buffer Solution	1M TBS(pH7.4) with 1% BSA, 3% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Tissue Specificity: Widely expressed. SWISS: O60701 Gene ID: 7358 Database links: Entrez Gene: 7358 Human Entrez Gene: 22235 Mouse Entrez Gene: 83472 Rat SwissProt: O60701 Human SwissProt: O70475 Mouse SwissProt: O70199 Rat Catalyzes the formation of UDP-α-D-glucuronate, which is a component of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Essential for embryonic development through its role in glycosaminoglycan biosynthesis. Essential for the normal development of the brain and neurons.

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